UCP2 DEFICIENCY INCREASES COLON TUMORIGENESIS BY PROMOTING LIPID SYNTHESIS AND DEPLETING NADPH FOR ANTIOXIDANT DEFENSES

UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses

Summary: Colorectal cancer (CRC) is associated with metabolic and redox perturbation.The mitochondrial transporter uncoupling protein 2 (UCP2) controls cell proliferation in vitro through the modulation of cellular metabolism, but the underlying mechanism in tumors in vivo remains unexplored.Using murine intestinal cancer models and CRC patient sam

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TAYIKISTAN, ENTRE APARENTE ESTABILIDAD Y NUEVOS RETOS

Geographical isolation, poor political relevance of the country during the period of its membership in the USSR, weak ethnic, religious, linguistic and regional cohesion resulted in the delay of the period of consolidation of a functional and stable government in Dushanbe for almost a decade after the dissolution of the Dining Bench Soviet Union.Wh

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